Name: TBC1D5 Rabbit Polyclonal Description: Rabbit Polyclonal Antibody to TBC1D5 Specificity: Human, Mouse ,Rat Applications: ELISA, WB, IHC, IP Immunogen: TBC1 domain family, member 5 Host: Rabbit Clonality: Polyclonal Isotype: IgG Conjugate: Unconjugated Purity: Immunogen affinity purified (≥95% as determined by SDS-PAGE) Product Form: Liquid Formulation: PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
May act as a GTPase-activating protein(GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity(PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network(TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy(PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes(PubMed:24603492).
Synonyms: KIAA0210 Antibody
TBC1 domain family member 5 Antibody
Please Note: TBC1D5 Rabbit Polyclonal is for research use only. It is not intended for diagnostic or therapeutic use. .