Name: SSTR2 Rabbit Polyclonal Description: Rabbit Polyclonal Antibody to SSTR2 Specificity: Human Applications: ELISA, IHC Immunogen: somatostatin receptor 2 Host: Rabbit Clonality: Polyclonal Isotype: IgG Conjugate: Unconjugated Purity: Immunogen affinity purified (≥95% as determined by SDS-PAGE) Product Form: Liquid Formulation: PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
Receptor for somatostatin-14 and-28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha-and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.
Synonyms: Somatostatin Receptor 2 Antibody
Somatostatin receptor type 2 Antibody
Neuroscience → Neurotransmitter → Neuropeptides → HormonesNeuroscience → Neurotransmission → Receptors / Channels → GPCR → More GPCRNeuroscience → Neurology process → Neuroendocrinology → GH RegulationCancer → Cancer Metabolism → Metabolic signaling pathway → Hormone biosynthesisMetabolism → Pathways and Processes → Endocrine metabolism → Hormone biosynthesis
Please Note: SSTR2 Rabbit Polyclonal is for research use only. It is not intended for diagnostic or therapeutic use.