Name:
SIRT5 Rabbit Polyclonal
 
Description:
Rabbit Polyclonal Antibody to SIRT5
Specificity:
Human, Mouse ,Rat
Applications:
ELISA, WB, IP (Recommended dilution:WB: 1:500-1:1000; IP: 1:500-1:1000; IF: 1:50-1:500)
Immunogen:
sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae), Calculated MW:33 kDa
Host:
Rabbit
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Unconjugated
Purity:
Immunogen affinity purified (≥95% as determined by SDS-PAGE)
Product Form:
Liquid
Formulation:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles
Background
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins(PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting(PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species(PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2(By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c(CYCS) and a number of other proteins in vitro such as UOX
Uniprot information:
Gene Name
SIRT5
Uniprot ID
Q9NXA8
Targets:
Synonyms:
NAD dependent deacetylase sirtuin 5 Antibody
NAD dependent lysine demalonylase and desuccinylase sirtuin 5 mitochondrial Antibody
NAD dependent protein deacylase sirtuin 5 mitochondrial Antibody
NAD-dependent protein deacylase sirtuin-5, mitochondrial Antibody
Regulatory protein SIR2 homolog 5 Antibody
Silent mating type information regulation 2 S.cerevisiae homolog 5 Antibody
Sir2 like 5 Antibody
SIR2-like protein 5 Antibody
SIR2L5 Antibody
SIR5_HUMAN Antibody
SIRT5 Antibody
Sirtuin 5 Antibody
Sirtuin type 5 Antibody
Research Areas:
Epigenetics and Nuclear Signaling → Chromatin Modifying Enzymes → Acetylation Epigenetics and Nuclear Signaling → Chromatin Modifying Enzymes → Acetylation → HDACs → Class III / Sir2 class Cardiovascular → Heart → Cardiac metabolism Metabolism → Types of disease → Cancer 
 
Please Note: SIRT5 Rabbit Polyclonal is for research use only. It is not intended for diagnostic or therapeutic use.