Name: SIRT5 Rabbit Polyclonal
 
Description: Rabbit Polyclonal Antibody to SIRT5
Specificity: Human, Mouse ,Rat
Applications: ELISA, WB, IP (Recommended dilution:WB: 1:500-1:1000; IP: 1:500-1:1000; IF: 1:50-1:500)
Immunogen: sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae), Calculated MW:33 kDa
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purity: Immunogen affinity purified (≥95% as determined by SDS-PAGE)
Product Form: Liquid
Formulation: PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles
Background

NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins(PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting(PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species(PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2(By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c(CYCS) and a number of other proteins in vitro such as UOX

Uniprot information:

Gene Name

SIRT5

Uniprot ID

Q9NXA8

Targets:

Synonyms:
  • NAD dependent deacetylase sirtuin 5 Antibody
  • NAD dependent lysine demalonylase and desuccinylase sirtuin 5 mitochondrial Antibody
  • NAD dependent protein deacylase sirtuin 5 mitochondrial Antibody
  • NAD-dependent protein deacylase sirtuin-5, mitochondrial Antibody
  • Regulatory protein SIR2 homolog 5 Antibody
  • Silent mating type information regulation 2 S.cerevisiae homolog 5 Antibody
  • Sir2 like 5 Antibody
  • SIR2-like protein 5 Antibody
  • SIR2L5 Antibody
  • SIR5_HUMAN Antibody
  • SIRT5 Antibody
  • Sirtuin 5 Antibody
  • Sirtuin type 5 Antibody

Research Areas:

Epigenetics and Nuclear Signaling → Chromatin Modifying Enzymes → Acetylation Epigenetics and Nuclear Signaling → Chromatin Modifying Enzymes → Acetylation → HDACs → Class III / Sir2 class Cardiovascular → Heart → Cardiac metabolism Metabolism → Types of disease → Cancer

 

Please Note: SIRT5 Rabbit Polyclonal is for research use only. It is not intended for diagnostic or therapeutic use.

 

 

 

 

SIRT5 Rabbit Polyclonal

SKU: MB07883
$300Price
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