Name: | SIRT5 Rabbit Polyclonal |
Description: | Rabbit Polyclonal Antibody to SIRT5 |
Specificity: | Human, Mouse ,Rat |
Applications: | ELISA, WB, IP (Recommended dilution:WB: 1:500-1:1000; IP: 1:500-1:1000; IF: 1:50-1:500) |
Immunogen: | sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae), Calculated MW:33 kDa |
Host: | Rabbit |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Unconjugated |
Purity: | Immunogen affinity purified (≥95% as determined by SDS-PAGE) |
Product Form: | Liquid |
Formulation: | PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles |
Background |
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins(PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting(PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species(PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2(By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c(CYCS) and a number of other proteins in vitro such as UOX |
Uniprot information:
Gene Name | SIRT5 |
Uniprot ID | Q9NXA8 |
Targets:
Synonyms: |
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Research Areas:
Epigenetics and Nuclear Signaling → Chromatin Modifying Enzymes → Acetylation Epigenetics and Nuclear Signaling → Chromatin Modifying Enzymes → Acetylation → HDACs → Class III / Sir2 class Cardiovascular → Heart → Cardiac metabolism Metabolism → Types of disease → Cancer
Please Note: SIRT5 Rabbit Polyclonal is for research use only. It is not intended for diagnostic or therapeutic use.