Name: | SIRT4 Rabbit Polyclonal |
Description: | Rabbit Polyclonal Antibody to SIRT4 |
Specificity: | Human, Mouse |
Applications: | ELISA, WB, IHC |
Immunogen: | sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae) |
Host: | Rabbit |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Unconjugated |
Purity: | Immunogen affinity purified (≥95% as determined by SDS-PAGE) |
Product Form: | Liquid |
Formulation: | PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.) |
Background |
Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase(PubMed:19220062). Catalyzes more efficiently removal of lipoyl-and biotinyl-than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex(PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner(PubMed:25525879). Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest(PubMed:16959573). In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation(PubMed:23663782). Acts as a tumor suppressor(PubMed:23562301, PubMed:23663782). Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of ‘Lys-471’ of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis(PubMed:23746352). Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1:PPARA interaction probably through the regulation of NAD(+) levels(PubMed:24043310, PubMed:20685656). Down-regulates insulin secretion(By similarity). |
Uniprot information:
Gene Name | SIRT4 |
Uniprot ID | Q8R216 |
Targets:
Synonyms: |
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Research Areas:
Epigenetics and Nuclear Signaling → Chromatin Modifying Enzymes → ADP-ribosylationSignal Transduction → Metabolism → Energy MetabolismCell Biology → Other Antibodies → Other AntibodiesEpigenetics and Nuclear Signaling → Chromatin Modifying Enzymes → Acetylation → HDACs → Class III / Sir2 classCardiovascular → Atherosclerosis → Diabetes associatedCardiovascular → Heart → Cardiac metabolismMetabolism → Pathways and Processes → Metabolic signaling pathways → Energy transfer pathways → Energy MetabolismMetabolism → Types of disease → DiabetesMetabolism → Types of disease → Heart disease
Please Note: SIRT4 Rabbit Polyclonal is for research use only. It is not intended for diagnostic or therapeutic use.