Name:
SIRT4 Rabbit Polyclonal
 
Description:
Rabbit Polyclonal Antibody to SIRT4
Specificity:
Human, Mouse
Applications:
ELISA, WB, IHC
Immunogen:
sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae)
Host:
Rabbit
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Unconjugated
Purity:
Immunogen affinity purified (≥95% as determined by SDS-PAGE)
Product Form:
Liquid
Formulation:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
Background
Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase(PubMed:19220062). Catalyzes more efficiently removal of lipoyl-and biotinyl-than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex(PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner(PubMed:25525879). Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest(PubMed:16959573). In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation(PubMed:23663782). Acts as a tumor suppressor(PubMed:23562301, PubMed:23663782). Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of ‘Lys-471’ of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis(PubMed:23746352). Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1:PPARA interaction probably through the regulation of NAD(+) levels(PubMed:24043310, PubMed:20685656). Down-regulates insulin secretion(By similarity).
Uniprot information:
Gene Name
SIRT4
Uniprot ID
Q8R216
Targets:
Synonyms:
MGC130046 Antibody
MGC130047 Antibody
MGC57437 Antibody
NAD dependent deacetylase sirtuin 4 Antibody
NAD dependent protein deacetylase sirtuin 4 Antibody
NAD-dependent ADP-ribosyltransferase sirtuin-4 Antibody
NAD-dependent protein deacetylase sirtuin-4 Antibody
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial Antibody
Regulatory protein SIR2 homolog 4 Antibody
Silent mating type information regulation 2 homolog Antibody
Sir 2 like 4 Antibody
SIR 2 like protein 4 Antibody
Sir2 like 4 Antibody
SIR2 like protein 4 Antibody
SIR2-like protein 4 Antibody
SIR2L 4 Antibody
SIR2L4 Antibody
SIR4_HUMAN Antibody
SIRT 4 Antibody
SIRT4 Antibody
Sirtuin (silent mating type information regulation 2 homolog) 4 Antibody
Sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae) Antibody
Sirtuin 4 Antibody
Sirtuin type 4 Antibody
Sirtuin-4 Antibody
Sirtuin4 Antibody
Research Areas:
Epigenetics and Nuclear Signaling → Chromatin Modifying Enzymes → ADP-ribosylation
Signal Transduction → Metabolism → Energy Metabolism
Cell Biology → Other Antibodies → Other Antibodies
Epigenetics and Nuclear Signaling → Chromatin Modifying Enzymes → Acetylation → HDACs → Class III / Sir2 class
Cardiovascular → Atherosclerosis → Diabetes associated
Cardiovascular → Heart → Cardiac metabolism
Metabolism → Pathways and Processes → Metabolic signaling pathways → Energy transfer pathways → Energy Metabolism
Metabolism → Types of disease → Diabetes
Metabolism → Types of disease → Heart disease
 
Please Note: SIRT4 Rabbit Polyclonal is for research use only. It is not intended for diagnostic or therapeutic use.