Name: SIRT4 Rabbit Polyclonal
 
Description: Rabbit Polyclonal Antibody to SIRT4
Specificity: Human, Mouse
Applications: ELISA, WB, IHC
Immunogen: sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purity: Immunogen affinity purified (≥95% as determined by SDS-PAGE)
Product Form: Liquid
Formulation: PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
Background

Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase(PubMed:19220062). Catalyzes more efficiently removal of lipoyl-and biotinyl-than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex(PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner(PubMed:25525879). Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest(PubMed:16959573). In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation(PubMed:23663782). Acts as a tumor suppressor(PubMed:23562301, PubMed:23663782). Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of ‘Lys-471’ of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis(PubMed:23746352). Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1:PPARA interaction probably through the regulation of NAD(+) levels(PubMed:24043310, PubMed:20685656). Down-regulates insulin secretion(By similarity).

Uniprot information:

Gene Name

SIRT4

Uniprot ID

Q8R216

Targets:

Synonyms:
  • MGC130046 Antibody
  • MGC130047 Antibody
  • MGC57437 Antibody
  • NAD dependent deacetylase sirtuin 4 Antibody
  • NAD dependent protein deacetylase sirtuin 4 Antibody
  • NAD-dependent ADP-ribosyltransferase sirtuin-4 Antibody
  • NAD-dependent protein deacetylase sirtuin-4 Antibody
  • NAD-dependent protein lipoamidase sirtuin-4, mitochondrial Antibody
  • Regulatory protein SIR2 homolog 4 Antibody
  • Silent mating type information regulation 2 homolog Antibody
  • Sir 2 like 4 Antibody
  • SIR 2 like protein 4 Antibody
  • Sir2 like 4 Antibody
  • SIR2 like protein 4 Antibody
  • SIR2-like protein 4 Antibody
  • SIR2L 4 Antibody
  • SIR2L4 Antibody
  • SIR4_HUMAN Antibody
  • SIRT 4 Antibody
  • SIRT4 Antibody
  • Sirtuin (silent mating type information regulation 2 homolog) 4 Antibody
  • Sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae) Antibody
  • Sirtuin 4 Antibody
  • Sirtuin type 4 Antibody
  • Sirtuin-4 Antibody
  • Sirtuin4 Antibody

Research Areas:

Epigenetics and Nuclear Signaling Chromatin Modifying Enzymes ADP-ribosylation
Signal Transduction Metabolism Energy Metabolism
Cell Biology Other Antibodies Other Antibodies
Epigenetics and Nuclear Signaling Chromatin Modifying Enzymes Acetylation HDACs Class III / Sir2 class
Cardiovascular Atherosclerosis Diabetes associated
Cardiovascular Heart Cardiac metabolism
Metabolism Pathways and Processes Metabolic signaling pathways Energy transfer pathways Energy Metabolism
Metabolism Types of disease Diabetes
Metabolism Types of disease Heart disease

 

Please Note: SIRT4 Rabbit Polyclonal is for research use only. It is not intended for diagnostic or therapeutic use.

 

 

 

 

SIRT4 Rabbit Polyclonal

SKU: MB07882
$330Price
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