Name: | SIRT2 Rabbit Polyclonal |
Description: | Rabbit Polyclonal Antibody to SIRT2 |
Specificity: | Human, Mouse , Rat |
Applications: | ELISA, WB, IHC, IP (Recommended dilution:WB: 1:500 – 1:2000; IHC: 1:50 – 1:200; IF: 1:10 – 1:100) |
Immunogen: | sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae), Synonyms:SIR2L, SIR2L2 |
Host: | Rabbit |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Unconjugated |
Purity: | Immunogen affinity purified (≥95% as determined by SDS-PAGE) |
Product Form: | Liquid |
Formulation: | PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.) |
Background |
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. |
Uniprot information:
Gene Name | SIRT2 |
Uniprot ID | Q8IXJ6 |
Targets:
Synonyms: |
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Research Areas:
Epigenetics and Nuclear Signaling → Chromatin Modifying Enzymes → Acetylation
Signal Transduction → Cytoskeleton / ECM → Cytoskeleton → Microtubules → TubulinEpigenetics and Nuclear Signaling → Chromatin Modifying Enzymes → Acetylation → HDACs → Class I
Please Note: SIRT2 Rabbit Polyclonal is for research use only. It is not intended for diagnostic or therapeutic use.