Name: | SIRT1 Rabbit Polyclonal |
Description: | Rabbit Polyclonal Antibody to SIRT1 |
Specificity: | Human, Mouse ,Rat |
Applications: | ELISA, IP, IHC, WB (Recommended dilution:WB: 1:500 – 1:2000; IHC: 1:50 – 1:200; IP: 1:50 – 1:100) |
Immunogen: | sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), SynonymsSIR2L1, Calculated MW: 130 kDa |
Host: | Rabbit |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Unconjugated |
Purity: | Immunogen affinity purified |
Product Form: | Liquid |
Formulation: | PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.) |
Background |
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. |
Uniprot information:
Gene Name | SIRT1 |
Uniprot ID | Q96EB6 |
Targets:
Synonyms: |
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Research Areas:
Cell Biology → Apoptosis → Intracellular → p53 Pathway
Epigenetics and Nuclear Signaling → Chromatin Modifying Enzymes → AcetylationMicrobiology → Interspecies Interaction → Host Virus InteractionTags & Cell Markers → Subcellular Markers → Nucleus → Other Nuclear BodiesEpigenetics and Nuclear Signaling → Chromatin Modifying Enzymes → Acetylation → HDACs → Class III / Sir2 classMetabolism → Types of disease → Obesity
Please Note: SIRT1 Rabbit Polyclonal is for research use only. It is not intended for diagnostic or therapeutic use.