Name:
PAK4 Rabbit Polyclonal
 
Description:
Rabbit Polyclonal Antibody to PAK4
Specificity:
Human, Mouse ,Rat
Applications:
ELISA, WB, IHC, IF, FC, IP
Immunogen:
p21 protein (Cdc42/Rac)-activated kinase 4
Host:
Rabbit
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Unconjugated
Purity:
Immunogen affinity purified (≥95% as determined by SDS-PAGE)
Product Form:
Liquid
Formulation:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
 
Background
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.
 
Uniprot information:
Gene Name
PAK4
Uniprot ID
O96013
 
Target:
Synonyms:
KIAA1142 Antibody
p21 activated kinase 4 Antibody
p21 Cdc42/Rac1-actiated kinase 4 Antibody
P21 protein (Cdc42/Rac) activated kinase 4 Antibody
p21(CDKN1A) activated kinase 4 Antibody
p21-activated kinase 4 Antibody
PAK 4 Antibody
PAK-4 Antibody
PAK4_HUMAN Antibody
Protein kinase related to S.cerevisiae STE20 effector for Cdc42Hs Antibody
Serine threonine kinase PAK 4 Antibody
Serine/threonine protein kinase PAK 4 Antibody
Serine/threonine protein kinase PAK4 Antibody
Serine/threonine-protein kinase PAK 4 Antibody
 
Research Areas:
Cell Biology → Cell Cycle → Kinases/Phosphatases → Other
Cell Biology → Apoptosis → Intracellular → Kinases
Signal Transduction → Cytoskeleton / ECM → Cytoskeleton → Microfilaments → Actin etc → Actin
Signal Transduction → Protein Phosphorylation → Ser / Thr Kinases → Other Kinases
Cancer → Cell cycle → Kinases/phosphatases → Other
 
Please Note: PAK4 Rabbit Polyclonal is for research use only. It is not intended for diagnostic or therapeutic use.