Name:
OAS2 Rabbit Polyclonal
 
Description:
Rabbit Polyclonal Antibody to OAS2
Specificity:
Human, Mouse
Applications:
ELISA, WB, IHC, IF, IP
Immunogen:
2'-5'-oligoadenylate synthetase 2, 66/71kDa
Host:
Rabbit
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Unconjugated
Purity:
Immunogen affinity purified (≥95% as determined by SDS-PAGE)
Product Form:
Liquid
Formulation:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
 
Background
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2′-5′-oligoadenylates(2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L(RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.
 
Uniprot information:
Gene Name
OAS2
Uniprot ID
P29728
 
Target:
Synonyms:
(2-5'')oligo(A) synthase 2 Antibody
(2-5')oligo(A) synthetase 2 Antibody
2''-5''-oligoadenylate synthase 2 Antibody
2'-5'-oligoadenylate synthetase 2 Antibody
2'-5'-oligoadenylate synthetase 2, 69/71kDa Antibody
2-5A synthase 2 Antibody
2-5A synthetase 2 Antibody
2-prime, 5-prime-oligoadenylate synthetase 2 edit item name - 2-prime, 5-prime-oligoadenylate synthetase 2, 69-KD Antibody
2-prime, 5-prime-oligoadenylate synthetase 2 Antibody
MGC78578 Antibody
OAS2_HUMAN Antibody
p69 Antibody
p69 OAS / p71 OAS Antibody
p69OAS / p71OAS Antibody
 
Research Areas:
Immunology → Innate Immunity → Cytokines → Interferons
Epigenetics and Nuclear Signaling → DNA / RNA → RNA Processing → Other
Epigenetics and Nuclear Signaling → Chromatin Binding Proteins → DNA / RNA binding
 
Please Note: OAS2 Rabbit Polyclonal is for research use only. It is not intended for diagnostic or therapeutic use.