Name: OAS2 Rabbit Polyclonal
 
Description: Rabbit Polyclonal Antibody to OAS2
Specificity: Human, Mouse
Applications: ELISA, WB, IHC, IF, IP
Immunogen: 2'-5'-oligoadenylate synthetase 2, 66/71kDa
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purity: Immunogen affinity purified (≥95% as determined by SDS-PAGE)
Product Form: Liquid
Formulation: PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)

 

Background

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2′-5′-oligoadenylates(2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L(RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.

 

Uniprot information:

Gene Name

OAS2

Uniprot ID

P29728

 

Target:

Synonyms: (2-5'')oligo(A) synthase 2 Antibody
(2-5')oligo(A) synthetase 2 Antibody
2''-5''-oligoadenylate synthase 2 Antibody
2'-5'-oligoadenylate synthetase 2 Antibody
2'-5'-oligoadenylate synthetase 2, 69/71kDa Antibody
2-5A synthase 2 Antibody
2-5A synthetase 2 Antibody
2-prime, 5-prime-oligoadenylate synthetase 2 edit item name - 2-prime, 5-prime-oligoadenylate synthetase 2, 69-KD Antibody
2-prime, 5-prime-oligoadenylate synthetase 2 Antibody
MGC78578 Antibody
OAS2_HUMAN Antibody
p69 Antibody
p69 OAS / p71 OAS Antibody
p69OAS / p71OAS Antibody

 

Research Areas:

Immunology Innate Immunity Cytokines Interferons

Epigenetics and Nuclear Signaling DNA / RNA RNA Processing Other
Epigenetics and Nuclear Signaling Chromatin Binding Proteins DNA / RNA binding

 

Please Note: OAS2 Rabbit Polyclonal is for research use only. It is not intended for diagnostic or therapeutic use.

 

 

OAS2 Rabbit Polyclonal

SKU: MB05951
$270Price
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