Name: | OAS2 Rabbit Polyclonal |
Description: | Rabbit Polyclonal Antibody to OAS2 |
Specificity: | Human, Mouse |
Applications: | ELISA, WB, IHC, IF, IP |
Immunogen: | 2'-5'-oligoadenylate synthetase 2, 66/71kDa |
Host: | Rabbit |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Unconjugated |
Purity: | Immunogen affinity purified (≥95% as determined by SDS-PAGE) |
Product Form: | Liquid |
Formulation: | PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.) |
Background |
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2′-5′-oligoadenylates(2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L(RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. |
Uniprot information:
Gene Name | OAS2 |
Uniprot ID | P29728 |
Target:
Synonyms: | (2-5'')oligo(A) synthase 2 Antibody (2-5')oligo(A) synthetase 2 Antibody 2''-5''-oligoadenylate synthase 2 Antibody 2'-5'-oligoadenylate synthetase 2 Antibody 2'-5'-oligoadenylate synthetase 2, 69/71kDa Antibody 2-5A synthase 2 Antibody 2-5A synthetase 2 Antibody 2-prime, 5-prime-oligoadenylate synthetase 2 edit item name - 2-prime, 5-prime-oligoadenylate synthetase 2, 69-KD Antibody 2-prime, 5-prime-oligoadenylate synthetase 2 Antibody MGC78578 Antibody OAS2_HUMAN Antibody p69 Antibody p69 OAS / p71 OAS Antibody p69OAS / p71OAS Antibody |
Research Areas:
Immunology → Innate Immunity → Cytokines → Interferons
Epigenetics and Nuclear Signaling → DNA / RNA → RNA Processing → OtherEpigenetics and Nuclear Signaling → Chromatin Binding Proteins → DNA / RNA binding
Please Note: OAS2 Rabbit Polyclonal is for research use only. It is not intended for diagnostic or therapeutic use.