Name: | N-cadherin Mouse Monoclonal |
Description: | Mouse Monoclonal Antibody to N-cadherin |
Specificity: | Human, Pig, Mouse , Rat |
Applications: | ELISA, IHC, WB (Recommended dilutionWB: 1:1000-1:10000; IHC: 1:20-1:200) |
Immunogen: | cadherin 2, type 1, N-cadherin (neuronal) (Calculated MW:130 kDa ) |
Host: | Mouse |
Clonality: | Monoclonal |
Isotype: | IgG2a |
Conjugate: | Unconjugated |
Purity: | Protein A+G purification (≥95% as determined by SDS-PAGE) |
Product Form: | Liquid |
Formulation: | PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.) |
Background |
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density(By similarity). |
Uniprot information:
Gene Name | N-cadherin |
Uniprot ID | P19022 |
Targets:
Synonyms | Cadherin 2, CD325, CDH2, CDHN, CDw325, N cadherin, NCAD, N-cadherin, Neural cadherin |
Research Areas:
Please Note: N-cadherin Mouse Monoclonal is for research use only. It is not intended for diagnostic or therapeutic use.