Name: IMPA1 Rabbit Polyclonal Description: Rabbit Polyclonal Antibody to IMPA1 Specificity: Human, Mouse ,Rat Applications: ELISA, WB, IHC, IF Immunogen: inositol(myo)-1(or 4)-monophosphatase 1 Host: Rabbit Clonality: Polyclonal Isotype: IgG Conjugate: Unconjugated Purity: Immunogen affinity purified Product Form: Liquid Formulation: PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1, 4, 5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1, 3-diphosphate, myo-inositol-1, 4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti- manic and anti- depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.
Synonyms: IMP Antibody
IMP 1 Antibody
IMPA 1 Antibody
IMPase 1 Antibody
Inositol 1(or 4) monophosphatase Antibody
Inositol monophosphatase Antibody
Inositol monophosphatase 1 Antibody
Inositol(myo) 1(or 4) monophosphatase 1 Antibody
Inositol-1(or 4)-monophosphatase 1 Antibody
Lithium sensitive myo inositol monophosphatase A1 Antibody
Lithium-sensitive myo-inositol monophosphatase A1 Antibody
Neuroscience → Neurotransmission → Intracellular Signaling → PhosphatasesSignal Transduction → Signaling Pathway → Lipid Signaling → Lipid PhosphatasesSignal Transduction → Metabolism → Lipid metabolism
Please Note: IMPA1 Rabbit Polyclonal is for research use only. It is not intended for diagnostic or therapeutic use.