Name: | IMPA1 Rabbit Polyclonal |
Description: | Rabbit Polyclonal Antibody to IMPA1 |
Specificity: | Human, Mouse ,Rat |
Applications: | ELISA, WB, IHC, IF |
Immunogen: | inositol(myo)-1(or 4)-monophosphatase 1 |
Host: | Rabbit |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Unconjugated |
Purity: | Immunogen affinity purified |
Product Form: | Liquid |
Formulation: | PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.) |
Background |
This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1, 4, 5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1, 3-diphosphate, myo-inositol-1, 4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti- manic and anti- depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. |
Uniprot information:
Gene Name | IMPA1 |
Uniprot ID | P29218 |
Target:
Synonyms: | IMP Antibody IMP 1 Antibody IMPA Antibody IMPA 1 Antibody IMPA1_HUMAN Antibody IMPase Antibody IMPase 1 Antibody Inositol 1(or 4) monophosphatase Antibody Inositol monophosphatase Antibody Inositol monophosphatase 1 Antibody Inositol(myo) 1(or 4) monophosphatase 1 Antibody Inositol-1(or 4)-monophosphatase 1 Antibody Lithium sensitive myo inositol monophosphatase A1 Antibody Lithium-sensitive myo-inositol monophosphatase A1 Antibody |
Research Areas:
Neuroscience → Neurotransmission → Intracellular Signaling → Phosphatases
Signal Transduction → Signaling Pathway → Lipid Signaling → Lipid PhosphatasesSignal Transduction → Metabolism → Lipid metabolism
Please Note: IMPA1 Rabbit Polyclonal is for research use only. It is not intended for diagnostic or therapeutic use.