Name:

IL33 Mouse Monoclonal  

Description:

Mouse Monoclonal Antibody to IL33

Specificity:

Human

Applications:

ELISA, WB  (Recommended dilutionWB: 1:500-1:2000; IHC: 1:50-1:500)

Immunogen:

interleukin 33 (Calculated MW:35kd)

Host:

Mouse

Clonality:

Monoclonal

Isotype:

IgG1

Conjugate:

Unconjugated

Purity:

Protein A+G purification (≥95% as determined by SDS-PAGE)

Product Form:

Liquid

Formulation:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)

Background

Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells(PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an “alarmin”, that amplifies immune responses during tissue injury(PubMed:17853410, PubMed:18836528). In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets(PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation(PubMed:18787100).

Gene Name

IL33

Uniprot ID

O95760

Synonyms:

C9orf26 Antibody CHROMOSOME 9 OPEN READING FRAME 26 Antibody DKFZp586H0523 Antibody DVS27 Antibody DVS27 related protein Antibody IL 1F11 Antibody IL 33 Antibody IL-1F11 Antibody IL-33 Antibody IL1F11 Antibody IL33_HUMAN Antibody Interleukin 1 family member 11 Antibody Interleukin 33 Antibody INTERLEUKIN 33 NFHEV Antibody Interleukin 33 precursor Antibody Interleukin-1 family member 11 Antibody Interleukin-33 (109-270) Antibody Interleukin33 Antibody NF HEV Antibody NF-HEV Antibody NFEHEV Antibody NFHEV Antibody Nuclear factor for high endothelial venules Antibody Nuclear factor from high endothelial venules Antibody OTTHUMP00000021041 Antibody RP11 575C20.2 Antibody