Name: FOXP3 Rabbit Polyclonal Description: Rabbit Polyclonal Antibody to FOXP3 Specificity: human, Mouse Applications: ELISA, WB Immunogen: forkhead box P3 Host: Rabbit Clonality: Polyclonal Isotype: IgG Conjugate: Unconjugated Purity: Immunogen affinity purified Product Form: Liquid Formulation: PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon- gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (PubMed:17360565). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049). Inhibits the transcriptional activator activity of RORA (PubMed:18354202). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity).
Synonyms: AIID Antibody
Forkhead box P3 Antibody
Forkhead box protein P3 Antibody
Immune dysregulation polyendocrinopathy enteropathy X linked Antibody
Immunodeficiency polyendocrinopathy enteropathy X linked Antibody
Cell Biology → Cell Cycle → Cell Division → Chromatid CohesionEpigenetics and Nuclear Signaling → Transcription → Domain Families → Forkhead Box → FOXPImmunology → Adaptive Immunity → Regulatory T Cells
Please Note: FOXP3 Rabbit Polyclonal is for research use only. It is not intended for diagnostic or therapeutic use.