Name: FOXP1 Rabbit Polyclonal Description: Rabbit Polyclonal Antibody to FOXP1 Specificity: Human, Mouse , Rat Applications: ELISA, WB Immunogen: forkhead box P1 Host: Rabbit Clonality: Polyclonal Isotype: IgG Conjugate: Unconjugated Purity: Immunogen affinity purified Product Form: Liquid Formulation: PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintainance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18799727, PubMed:18347093). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093).
Isoform 8: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5′-CGATACAA-3′ (or closely related sequences) (PubMed:21924763). Promotes ESC self- renewal and pluripotency (By similarity).
Synonyms: 12CC4 Antibody
Fork head related protein like B Antibody
Forkhead box P1 Antibody
Forkhead box protein P1 Antibody
FOX P1 Antibody
FOXP 1 Antibody
Glutamine rich factor 1 Antibody
QRF 1 Antibody
Epigenetics and Nuclear Signaling → Transcription → Domain Families → Forkhead BoxEpigenetics and Nuclear Signaling → Transcription → Domain Families → Forkhead Box → FOXPCancer → Oncoproteins/suppressors → Tumor suppressors → Other
Please Note: FOXP1 Rabbit Polyclonal is for research use only. It is not intended for diagnostic or therapeutic use.