Name: | FGF1 Rabbit Polyclonal |
Description: | Rabbit Polyclonal Antibody to FGF1 |
Specificity: | human, Mouse , rat |
Applications: | ELISA, IHC |
Immunogen: | fibroblast growth factor 1 (acidic) |
Host: | Rabbit |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Unconjugated |
Purity: | Immunogen affinity purified |
Product Form: | Liquid |
Formulation: | PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.) |
Background |
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107). |
Uniprot information:
Gene Name | FGF1 |
Uniprot ID | P05230 |
Target:
Synonyms: | Acidic fibroblast growth factor Antibody aFGF Antibody Beta endothelial cell growth factor Antibody Beta-endothelial cell growth factor Antibody ECGF Antibody ECGF beta Antibody ECGF-beta Antibody ECGFA Antibody ECGFB Antibody Endothelial Cell Growth Factor alpha Antibody Endothelial Cell Growth Factor beta Antibody FGF 1 Antibody FGF alpha Antibody FGF1_HUMAN Antibody FGFA Antibody Fibroblast growth factor 1 Antibody Fibroblast Growth Factor 1 Acidic Antibody GLIO703 Antibody HBGF 1 Antibody HBGF-1 Antibody HBGF1 Antibody Heparin binding growth factor 1 Antibody Heparin binding growth factor 1 precursor Antibody Heparin-binding growth factor 1 Antibody |
Research Areas:
Cardiovascular → Angiogenesis → Growth Factors → FGF → FGF
Signal Transduction → Growth Factors/Hormones → FGFCancer → Growth factors → FGF
Please Note: FGF1 Rabbit Polyclonal is for research use only. It is not intended for diagnostic or therapeutic use.