Name:
FGF1 Rabbit Polyclonal
 
Description:
Rabbit Polyclonal Antibody to FGF1
Specificity:
human, Mouse , rat
Applications:
ELISA, IHC
Immunogen:
fibroblast growth factor 1 (acidic)
Host:
Rabbit
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Unconjugated
Purity:
Immunogen affinity purified
Product Form:
Liquid
Formulation:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
 
Background
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107).
 
Uniprot information:
Gene Name
FGF1
Uniprot ID
P05230
 
Target:
Synonyms:
Acidic fibroblast growth factor Antibody
aFGF Antibody
Beta endothelial cell growth factor Antibody
Beta-endothelial cell growth factor Antibody
ECGF Antibody
ECGF beta Antibody
ECGF-beta Antibody
ECGFA Antibody
ECGFB Antibody
Endothelial Cell Growth Factor alpha Antibody
Endothelial Cell Growth Factor beta Antibody
FGF 1 Antibody
FGF alpha Antibody
FGF1_HUMAN Antibody
FGFA Antibody
Fibroblast growth factor 1 Antibody
Fibroblast Growth Factor 1 Acidic Antibody
GLIO703 Antibody
HBGF 1 Antibody
HBGF-1 Antibody
HBGF1 Antibody
Heparin binding growth factor 1 Antibody
Heparin binding growth factor 1 precursor Antibody
Heparin-binding growth factor 1 Antibody
 
Research Areas:
Cardiovascular → Angiogenesis → Growth Factors → FGF → FGF
Signal Transduction → Growth Factors/Hormones → FGF
Cancer → Growth factors → FGF
 
Please Note: FGF1 Rabbit Polyclonal is for research use only. It is not intended for diagnostic or therapeutic use.