Name:

EXOSC2 Mouse Monoclonal  

Description:

Mouse Monoclonal Antibody to EXOSC2

Specificity:

Human

Applications:

ELISA, WB, IF, IHC

Immunogen:

exosome component 2 (Calculated MW:30-33 kDa)

Host:

Mouse

Clonality:

Monoclonal

Isotype:

IgG1

Conjugate:

Unconjugated

Purity:

Protein A+G purification (≥95% as determined by SDS-PAGE)

Product Form:

Liquid

Formulation:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)

Background

Non-catalytic component of the RNA exosome complex which has 3′->5′ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ‘pervasive’ transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination(CSR) and/or Ig variable region somatic hypermutation(SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3′ untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits(Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7.

Gene Name

EXOSC2

Uniprot ID

Q13868

Synonyms:

Exosome complex exonuclease RRP4 Antibody Exosome component 2 Antibody Homolog of yeast RRP4 (ribosomal RNA processing 4), 3' 5' exoribonuclease (RRP4) Antibody Homolog of yeast RRP4 (ribosomal RNA processing 4), 3'-5'-exoribonuclease Antibody hRrp4p Antibody OTTHUMP00000022370 Antibody OTTHUMP00000022371 Antibody OTTHUMP00000022372 Antibody OTTHUMP00000022373 Antibody OTTHUMP00000022374 Antibody p7 Antibody Ribosomal RNA processing protein 4 Antibody RRP4 Antibody Rrp4p Antibody