Name:
EXOSC2 Mouse Monoclonal
 
Description:
Mouse Monoclonal Antibody to EXOSC2
Specificity:
Human
Applications:
ELISA, WB, IF, IHC
Immunogen:
exosome component 2 (Calculated MW:30-33 kDa)
Host:
Mouse
Clonality:
Monoclonal
Isotype:
IgG1
Conjugate:
Unconjugated
Purity:
Protein A+G purification (≥95% as determined by SDS-PAGE)
Product Form:
Liquid
Formulation:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
 
Background
Non-catalytic component of the RNA exosome complex which has 3′->5′ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ‘pervasive’ transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination(CSR) and/or Ig variable region somatic hypermutation(SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3′ untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits(Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7.
 
Uniprot information:
Gene Name
EXOSC2
Uniprot ID
Q13868
 
Target:
Synonyms:
Exosome complex exonuclease RRP4 Antibody
Exosome component 2 Antibody
Homolog of yeast RRP4 (ribosomal RNA processing 4), 3' 5' exoribonuclease (RRP4) Antibody
Homolog of yeast RRP4 (ribosomal RNA processing 4), 3'-5'-exoribonuclease Antibody
hRrp4p Antibody
OTTHUMP00000022370 Antibody
OTTHUMP00000022371 Antibody
OTTHUMP00000022372 Antibody
OTTHUMP00000022373 Antibody
OTTHUMP00000022374 Antibody
p7 Antibody
Ribosomal RNA processing protein 4 Antibody
RRP4 Antibody
Rrp4p Antibody
 
Research Areas:
Epigenetics and Nuclear Signaling → DNA / RNA → Translation → Regulation
Epigenetics and Nuclear Signaling → DNA / RNA → RNA Processing → Other
 
Please Note: EXOSC2 Mouse Monoclonal is for research use only. It is not intended for diagnostic or therapeutic use.