Name: | ECD Rabbit Polyclonal |
Description: | Rabbit Polyclonal Antibody to ECD |
Specificity: | Human, Mouse |
Applications: | ELISA, WB, IF, IP |
Immunogen: | ecdysoneless homolog (Drosophila) |
Host: | Rabbit |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Unconjugated |
Purity: | Immunogen affinity purified |
Product Form: | Liquid |
Formulation: | PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.) |
Background |
Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212). |
Uniprot information:
Gene Name | ECD |
Uniprot ID | O95905 |
Target:
Synonyms: | Ecdysoneless homolog Antibody ECD_HUMAN Antibody hSGT1 Antibody Human suppressor of GCR two Antibody Protein ecdysoneless homolog Antibody SGT 1 Antibody SGT1 Antibody SGT1 protein Antibody Suppressor of GCR2 Antibody |
Research Areas:
Signal Transduction → Metabolism → Energy Metabolism
Epigenetics and Nuclear Signaling → Transcription → Other factorsMetabolism → Pathways and Processes → Metabolic signaling pathways → Energy transfer pathways → Energy MetabolismMetabolism → Types of disease → Cancer
Please Note: ECD Rabbit Polyclonal is for research use only. It is not intended for diagnostic or therapeutic use.