Name: DDR1 Rabbit Polyclonal Description: Rabbit Polyclonal Antibody to DDR1 Specificity: Human, Mouse ,Rat Applications: ELISA, IHC Immunogen: discoidin domain receptor tyrosine kinase 1 Host: Rabbit Clonality: Polyclonal Isotype: IgG Conjugate: Unconjugated Purity: Immunogen affinity purified Product Form: Liquid Formulation: PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
Background Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
Uniprot information:
Gene Name DDR1
Uniprot ID Q08345
Target:
Synonyms CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE
Research Areas:
Please Note: DDR1 Rabbit Polyclonal is for research use only. It is not intended for diagnostic or therapeutic use.