Name: | CX3CL1 Mouse Monoclonal |
Description: | Mouse Monoclonal Antibody to CX3CL1 |
Specificity: | Human |
Applications: | ELISA, WB |
Immunogen: | chemokine (C-X3-C motif) ligand 1 (Calculated MW: 90-100 kDa) |
Host: | Mouse |
Clonality: | Monoclonal |
Isotype: | IgG1 |
Conjugate: | Unconjugated |
Purity: | Protein A+G purification (≥95% as determined by SDS-PAGE) |
Product Form: | Liquid |
Formulation: | PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.) |
Background |
Acts as a ligand for both CX3CL1 and integrins. Binds to CX3CR1(PubMed:23125415, PubMed:9931005, PubMed:21829356). Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site(site 1) in integrins. In the absence of CX3CR1, binds to a second site(site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1(PubMed:23125415, PubMed:24789099). The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium(PubMed:9024663, PubMed:9177350). |
Uniprot information:
Gene Name | CX3CL1 |
Uniprot ID | P78423 |
Target:
Synonyms: | A 152E5.2 Antibody AB030188 Antibody ABCD 3 Antibody ABCD3 Antibody AI848747 Antibody C-X3-C motif chemokine 1 Antibody C3Xkine Antibody Chemokine (C-X3-C motif) ligand 1 Antibody Chemokine C X3 C motif ligand 1 Antibody Chemokine CX3C Motif Ligand 1 Antibody CX3C membrane anchored chemokine Antibody CX3C membrane-anchored chemokine Antibody CXC 3 Antibody CXC3 Antibody CXC3C Antibody D8Bwg0439e Antibody FKN Antibody Fractalkine Antibody Neurotactin Antibody NTN Antibody NTT Antibody Processed fractalkine Antibody SCYD 1 Antibody SCYD1 Antibody Small inducible cytokine D1 Antibody Small inducible cytokine subfamily D (Cys X3 Cys) member 1 Antibody small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin) Antibody Small inducible cytokine subfamily D member 1 Antibody Small-inducible cytokine D1 Antibody X3CL1_HUMAN Antibody |
Research Areas:
Immunology → Innate Immunity → Macrophage / Inflamm.
Immunology → Innate Immunity → Chemokines → Delta Chemokines (CXC3)Cardiovascular → Atherosclerosis → Vascular Inflammation → Leukocyte recruitment → Chemokines
Please Note: CX3CL1 Mouse Monoclonal is for research use only. It is not intended for diagnostic or therapeutic use.