Name:
CX3CL1 Mouse Monoclonal
 
Description:
Mouse Monoclonal Antibody to CX3CL1
Specificity:
Human
Applications:
ELISA, WB
Immunogen:
chemokine (C-X3-C motif) ligand 1 (Calculated MW: 90-100 kDa)
Host:
Mouse
Clonality:
Monoclonal
Isotype:
IgG1
Conjugate:
Unconjugated
Purity:
Protein A+G purification (≥95% as determined by SDS-PAGE)
Product Form:
Liquid
Formulation:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
 
Background
Acts as a ligand for both CX3CL1 and integrins. Binds to CX3CR1(PubMed:23125415, PubMed:9931005, PubMed:21829356). Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site(site 1) in integrins. In the absence of CX3CR1, binds to a second site(site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1(PubMed:23125415, PubMed:24789099). The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium(PubMed:9024663, PubMed:9177350).
 
Uniprot information:
Gene Name
CX3CL1
Uniprot ID
P78423
 
Target:
Synonyms:
A 152E5.2 Antibody
AB030188 Antibody
ABCD 3 Antibody
ABCD3 Antibody
AI848747 Antibody
C-X3-C motif chemokine 1 Antibody
C3Xkine Antibody
Chemokine (C-X3-C motif) ligand 1 Antibody
Chemokine C X3 C motif ligand 1 Antibody
Chemokine CX3C Motif Ligand 1 Antibody
CX3C membrane anchored chemokine Antibody
CX3C membrane-anchored chemokine Antibody
CXC 3 Antibody
CXC3 Antibody
CXC3C Antibody
D8Bwg0439e Antibody
FKN Antibody
Fractalkine Antibody
Neurotactin Antibody
NTN Antibody
NTT Antibody
Processed fractalkine Antibody
SCYD 1 Antibody
SCYD1 Antibody
Small inducible cytokine D1 Antibody
Small inducible cytokine subfamily D (Cys X3 Cys) member 1 Antibody
small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin) Antibody
Small inducible cytokine subfamily D member 1 Antibody
Small-inducible cytokine D1 Antibody
X3CL1_HUMAN Antibody
 
Research Areas:
Immunology → Innate Immunity → Macrophage / Inflamm.
Immunology → Innate Immunity → Chemokines → Delta Chemokines (CXC3)
Cardiovascular → Atherosclerosis → Vascular Inflammation → Leukocyte recruitment → Chemokines
 
Please Note: CX3CL1 Mouse Monoclonal is for research use only. It is not intended for diagnostic or therapeutic use.