Name: | Caspase 8 Mouse Monoclonal |
Description: | Mouse Monoclonal Antibody to Caspase 8 |
Specificity: | Human |
Applications: | ELISA, IHC, WB |
Immunogen: | caspase 8, apoptosis-related cysteine peptidase (Calculated MW: 50-55 kDa, 25-32 kDa) |
Host: | Mouse |
Clonality: | Monoclonal |
Isotype: | IgG1 |
Conjugate: | Unconjugated |
Purity: | Protein A+G purification (≥95% as determined by SDS-PAGE) |
Product Form: | Liquid |
Formulation: | PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.) |
Recommended dilution | WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:100-1:400; IF: 1:50-1:500 |
Background |
Caspase 8, also named as MCH5, MACH, FLICE, and CAP4, belongs to the peptidase C14A family. It may participate in the GZMB apoptotic pathways and functions as an upstream regulator in a-bisabolol-induced apoptosis. Caspase 8 catalyzes an essential intermediate step in the ubiquitination and proteasome-mediated degradation of IRF3(PMID:21816816). It may control diabetic embryopathy-associated apoptosis via Caspase 8 is expressed as nine isoforms by alternative splicing with the molecular mass from 26 kDa to 62 kDa. 66093-1-AP can recognize pro-and cleaved-caspase 8. |
Uniprot information:
Gene Name | Caspase 8 |
Uniprot ID | Q14790 |
Target:
Synonyms: | ALPS2B Antibody Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein Antibody Apoptotic cysteine protease Antibody Apoptotic protease Mch-5 Antibody Apoptotic protease Mch5 Antibody CAP4 Antibody CASP-8 Antibody CASP8 Antibody CASP8_HUMAN Antibody Caspase 8 apoptosis related cysteine peptidase Antibody Caspase-8 Antibody Caspase-8 subunit p10 Antibody CED 3 Antibody FADD Like ICE Antibody FADD-homologous ICE/CED-3-like protease Antibody FADD-like ICE Antibody FLICE Antibody FLJ17672 Antibody ICE-like apoptotic protease 5 Antibody MACH Antibody MACH alpha 1/2/3 protein Antibody MACH beta 1/2/3/4 protein Antibody MCH5 Antibody MGC78473 Antibody MORT1 associated ced 3 homolog Antibody MORT1-associated CED-3 homolog Antibody OTTHUMP00000163717 Antibody OTTHUMP00000163720 Antibody OTTHUMP00000163724 Antibody OTTHUMP00000163725 Antibody OTTHUMP00000165062 Antibody OTTHUMP00000165063 Antibody OTTHUMP00000165064 Antibody OTTHUMP00000206552 Antibody OTTHUMP00000206582 Antibody |
Research Areas:
Please Note: Caspase 8 Mouse Monoclonal is for research use only. It is not intended for diagnostic or therapeutic use.