Name: APEX1 Rabbit Polyclonal
 
Description: Rabbit Polyclonal Antibody to APEX1
Specificity: human, Mouse , rat
Applications: ELISA, WB, IHC, IF
Immunogen: APEX nuclease (multifunctional DNA repair enzyme) 1
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purity: Immunogen affinity purified
Product Form: Liquid
Formulation: PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)

 

Uniprot information:

Gene Name

APEX1

Uniprot ID

P27695

 

Target:

Synonyms: AP endonuclease 1 Antibody
AP endonuclease class I Antibody
AP lyase Antibody
APE Antibody
APE 1 Antibody
APE-1 Antibody
APE1 Antibody
APEN Antibody
APEX Antibody
APEX 1 Antibody
APEX nuclease Antibody
APEX nuclease (multifunctional DNA repair enzyme) 1 Antibody
Apex nuclease 1 Antibody
APEX1_HUMAN Antibody
Apurinic endonuclease Antibody
Apurinic-apyrimidinic endonuclease 1 Antibody
Apurinic/apyrimidinic (abasic) endonuclease Antibody
Apurinic/apyrimidinic endonuclease 1 Antibody
Apurinic/apyrimidinic exonuclease Antibody
APX Antibody
BAP1 Antibody
Deoxyribonuclease (apurinic or apyrimidinic) Antibody
DNA (apurinic or apyrimidinic site) lyase Antibody
DNA-(apurinic or apyrimidinic site) lyase, mitochondrial Antibody
EC 4.2.99.18 Antibody
HAP 1 Antibody
HAP1 Antibody
Human Apurinic endonuclease 1 Antibody
MGC139790 Antibody
Multifunctional DNA repair enzyme Antibody
Redox factor 1 Antibody
Redox factor-1 Antibody
REF 1 Antibody
REF 1 protein Antibody
REF-1 Antibody
REF1 Antibody
REF1 protein Antibody

 

Research Areas:

Epigenetics and Nuclear Signaling DNA / RNA DNA Damage & Repair Base Excision Repair

Cardiovascular Heart Cardiogenesis Transcription factors/regulators

 

Please Note: APEX1 Rabbit Polyclonal is for research use only. It is not intended for diagnostic or therapeutic use.

 

APEX1 Rabbit Polyclonal

SKU: MB00479
$310Price
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    Ships in: 5-7 Business Days

     

    Background

    Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5′-deoxyribose phosphate and 3′-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3′-5′ exoribonuclease activity on mismatched deoxyribonucleotides at the 3′ termini of nicked or gapped DNA molecules during short-patch BER. Possesses a DNA 3′ phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3′ side of DNA strand breaks. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5′-terminal deoxyribose 5′- phosphate (dRp) excision activity of POLB. Plays a role in the protection from granzymes-mediated cellular repair leading to cell death. Also involved in the DNA cleavage step of class switch recombination (CSR). On the other hand, APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression. Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance. Acts also as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA. Binds DNA and RNA.

     

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