Name: IFIT3 Rabbit Polyclonal Description: Rabbit Polyclonal Antibody to IFIT3 Specificity: Human Applications: ELISA, WB, IP Immunogen: interferon-induced protein with tetratricopeptide repeats 3 Host: Rabbit Clonality: Polyclonal Isotype: IgG Conjugate: Unconjugated Purity: Immunogen affinity purified Product Form: Liquid Formulation: PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS- mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin- dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.
Synonyms: CIG 49 Antibody
GARG 49 Antibody
Interferon induced 60 kDa protein Antibody
Interferon induced protein 60 Antibody
Interferon induced protein with tetratricopeptide repeats 3 Antibody
Interferon-induced 60 kDa protein Antibody
Interferon-induced protein with tetratricopeptide repeats 3 Antibody
Interferon-induced protein with tetratricopeptide repeats 4 Antibody
Retinoic acid induced gene G protein Antibody
Retinoic acid-induced gene G protein Antibody
RIG G Antibody
Immunology → Innate Immunity → Cytokines → Interferons
Please Note: IFIT3 Rabbit Polyclonal is for research use only. It is not intended for diagnostic or therapeutic use.