Name:

IFIT3 Rabbit Polyclonal  

Description:

Rabbit Polyclonal Antibody to IFIT3

Specificity:

Human

Applications:

ELISA, WB, IP

Immunogen:

interferon-induced protein with tetratricopeptide repeats 3

Host:

Rabbit

Clonality:

Polyclonal

Isotype:

IgG

Conjugate:

Unconjugated

Purity:

Immunogen affinity purified

Product Form:

Liquid

Formulation:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)

Background

IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS- mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin- dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.

Gene Name

IFIT3

Uniprot ID

O14879

Synonyms:

CIG 49 Antibody CIG49 Antibody GARG 49 Antibody IFI-60K Antibody IFI60 Antibody IFI60K Antibody IFIT-3 Antibody IFIT-4 Antibody IFIT3_HUMAN Antibody IFIT4 Antibody Interferon induced 60 kDa protein Antibody Interferon induced protein 60 Antibody Interferon induced protein with tetratricopeptide repeats 3 Antibody Interferon-induced 60 kDa protein Antibody Interferon-induced protein with tetratricopeptide repeats 3 Antibody Interferon-induced protein with tetratricopeptide repeats 4 Antibody IRG2 Antibody ISG-60 Antibody ISG60 Antibody P60 Antibody Retinoic acid induced gene G protein Antibody Retinoic acid-induced gene G protein Antibody RIG G Antibody RIG-G Antibody RIGG Antibody RP11-149I23.4 Antibody