Name:
IFIT3 Rabbit Polyclonal
 
Description:
Rabbit Polyclonal Antibody to IFIT3
Specificity:
Human
Applications:
ELISA, WB, IP
Immunogen:
interferon-induced protein with tetratricopeptide repeats 3
Host:
Rabbit
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Unconjugated
Purity:
Immunogen affinity purified
Product Form:
Liquid
Formulation:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
 
Background
IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS- mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin- dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.
 
Uniprot information:
Gene Name
IFIT3
Uniprot ID
O14879
 
Target:
Synonyms:
CIG 49 Antibody
CIG49 Antibody
GARG 49 Antibody
IFI-60K Antibody
IFI60 Antibody
IFI60K Antibody
IFIT-3 Antibody
IFIT-4 Antibody
IFIT3_HUMAN Antibody
IFIT4 Antibody
Interferon induced 60 kDa protein Antibody
Interferon induced protein 60 Antibody
Interferon induced protein with tetratricopeptide repeats 3 Antibody
Interferon-induced 60 kDa protein Antibody
Interferon-induced protein with tetratricopeptide repeats 3 Antibody
Interferon-induced protein with tetratricopeptide repeats 4 Antibody
IRG2 Antibody
ISG-60 Antibody
ISG60 Antibody
P60 Antibody
Retinoic acid induced gene G protein Antibody
Retinoic acid-induced gene G protein Antibody
RIG G Antibody
RIG-G Antibody
RIGG Antibody
RP11-149I23.4 Antibody
 
Research Areas:
Immunology → Innate Immunity → Cytokines → Interferons
 
Please Note: IFIT3 Rabbit Polyclonal is for research use only. It is not intended for diagnostic or therapeutic use.